30 Bananas a Day!

Scientists learn how cancer tricks immune system - NOV 3023

Scientists learn how cancer tricks immune system
AM By Alison Caldwell
Posted Mon Nov 12, 2012 10:54am AEDT

 

 http://www.abc.net.au/news/2012-11-12/scientists-learn-how-cancer-c...

 

MAP: Melbourne 3000

Melbourne scientists say they have made a breakthrough in their research into how cancer cells can trick the body's immune system.

 

AUDIO: Researchers unlock how cancer deceives body (AM)
Researchers working with mice at the Peter MacCallum Cancer Centre say they have discovered a molecule that a cancer cell produces to convince the immune system that it poses no danger

Lead researcher Dr Dan Andrews says natural killer cells roam the body like a security team looking for disease.

They lock onto the surface of the molecule and if they find everything is fine, they move on.

 

"Cancer cells are capable... of over-expressing these locks on the surface of the system and they fool the natural killer cell into thinking everything is OK and that's how the cancer grows," he said.

Dr Andrews says it is a major step forward, but any application to cancer treatment is still a long way off.

 

"The next step is to look and see if this interaction is happening in humans," he said.

 

"All the work that we've done has been performed in mouse models."

There are hopes the finding could eventually lead to the development of new treatments to interrupt the deadly deception.

"It's taken us five years to get to this point and any translational effects that could flow through in the pipeline are at least 20, 25 years downstream from this," he said.

 

In collaboration with the University of Melbourne, the research has been funded by the National Health and Medical Research Council and by a foundation called Cancer Cure Australia, which helps fund junior researchers.

 

The research will be published in the scientific journal Nature Immunology.

Views: 78

Replies to This Discussion

How infection triggers autoimmune disease
Last Updated: Sunday, November 11, 2012,14:39 1
Tags: Infection, Autoimmune disease, Rheumatic fever

 

Washington: Australian scientists have confirmed a ``weak link`` in the immune system – identifying the exact conditions under which an infection can prompt the body to attack itself.

The medical community has long understood that autoimmune diseases such as rheumatic fever, wherein the body creates antibodies that attack the heart, can develop after the body tries to fight off infections.

But little was known about how these kinds of infection-driven autoimmunity occurred or why the body was unable to prevent them.

Tyani Chan and Robert Brink from Sydney``s Garvan Institute of Medical Research studied mice to investigate what could prompt an infection-driven autoimmune attack.

They were focused on the antibody-creating B cells that play a crucial role in the body`s response to disease.

When the body is fending off an infection, B cells can mutate their antibody genes randomly until they produce one that ``sticks`` to the invading antigen.

This process occurs within specialised environments in the lymph system known as ``germinal centres``.

Dr Chan and Associate Professor Brink demonstrated that when antigen is abundant and available throughout the body, rogue autoantibody-generating B cells are deleted and autoimmunity avoided.

But when target antigen is located only in a tissue or organ remote from the germinal centre, B cells capable of reacting against both antigen and ``self`` are able to escape the germinal centre and produce autoantibodies.

"Essentially we``ve shown there``s a big hole in self-tolerance when it comes to cross-reactive autoantibodies that can attack organ-specific targets," Associate Prof Brink said in a statement.

"Our finding explains a lot about how autoimmune conditions that target particular organs such as the heart or nervous system could develop after an infection.

"It also suggests that if you know enough about the disease and the molecular messaging systems involved, it may be possible in future to modulate the germinal centre response,” he added.

The study has been published in the prestigious international journal Immunity.

ANI

First Published: Sunday, November 11, 2012, 10:16
COMMENTS

RSS

About

TheBananaGirl created this Ning Network.

30BaD Search

Latest Activity

Aysel is now friends with Houdini Steve Owens and Sugalena
yesterday
OrganicMark posted a status
"Why the 2008 Housing Crisis Recovery Is Just an Illusion (w/ Keith Jurow) #evolution #awakening #peace #truth #light http://j.mp/2ODSZ93"
Tuesday
OrganicMark posted a status
"Not Transitory - Fed Liquidity Handout Surges To Near $90 Billion #evolution #awakening #peace #truth #love #light http://j.mp/35F4Sl5"
Tuesday
Frugisaurus and Alex Curtis-Slep are now friends
Monday
Michael Lanfield posted a video

Return to the Gentle Sea by Michael Lanfield with Music by Dr. Will Tuttle, PhD (Full Audiobook)

Return to the Gentle Sea: For the Love That Lives in Everyone is a book on spiritual healing and cultural transformation on the human relationship to nonhuman animals. It explains how living in a herding culture, eating animals and their secretions,…
Sunday
Michael Lanfield commented on ednshell's video
Sunday
Michael Lanfield and Olga are now friends
Sunday
Raw Aussie Athlete and Lil Green Coconut are now friends
Sunday
ednshell replied to Tams's discussion Best vegan retreats ?
Saturday
ednshell posted a video

Take Back Your Power 2017 (Official) - smart meter documentary

This award-winning film documents the real story on smart meters. + Subscribe for free EMF guide & help stop 'smart' meters and 5G: https://TakeBackYourPower...
Saturday
ednshell posted a discussion
Saturday
Profile Iconmichael wilson, Savannah Holte, tori jacobs and 2 more joined 30 Bananas a Day!
Saturday
OrganicMark posted a status
"QE4 "Not A QE" Begins: Fed Starts Buying $60BN In Bills Per Month Beginning Next Week #awakening #peace #truth #light http://j.mp/2M9cmoQ"
Oct 12
Rock and Tams are now friends
Oct 12
Tams posted a discussion
Oct 11
OrganicMark posted a status
"Powell says the Fed will start expanding its balance sheet ‘soon’ in response to funding issues #peace #truth #light http://j.mp/30Zc8ol"
Oct 11

© 2019   Created by TheBananaGirl.   Powered by

Badges  |  Report an Issue  |  Terms of Service