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Food RNA survives digestion, circulates in blood, and alters gene expression.

This study focuses on these newly discovered effects with cooked rice as the factor, but wouldn't it be interesting to do the same study using fruit-n-veg?

 

"Tiny RNAs usually found in plants have been discovered circulating in blood, and animal studies indicate that they are directly manipulating the expression of genes.

 

When they put the rice miRNA in cells, they found that levels of a receptor that filters out LDL, aka “bad” cholesterol, in the liver went down. As it turned out, the miRNA was binding to the receptor’s messenger RNA and preventing it from being expressed, sending receptor levels down and bad-cholesterol levels up."

 

 

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Yes, this is a fascinating study. I read about it recently and thought that this is just the beginning of the scientific understanding of the fact that we truly become what we eat. Perhaps some years from now the science will be able to validate that there is a dramatic difference between raw and cooked diets. When you think of this, since cooking destroys the molecular structure, this should have some measurable negative effect on some processes that are currently little understood.

"It’s only logical that what we eat has an effect on the expression of our genes, in the general sense that nutrients from food are involved in cellular processes that control and are controlled by gene expression. But this is an unusually direct route, and surprising from an organism that’s so different from mammals."

 

Why is it surprising that what we eat affects us on a cellular level?  I just don't understand what's new about this study.  

 

Also the study in reference was on MICE which are MAMMALS.  I wish people would pay more attention to what they're writing before they write it. :-)

"Why is it surprising that what we eat affects us on a cellular level?  I just don't understand what's new about this study."

 

What's new about the study is the scientific evidence for something that, although making sense, would otherwise be an opinion unsupported by such evidence.

 

While I agree with you in sentiment, the quote that I've referenced has an enormous contradictory statement.  Mice are mammals.  I'm just trying to get at what's new here.

 

Respect,

PJ

I do not understand your question. It's quite clear that the finding is new. Perhaps you can elaborate on what you mean?

If there are leftover parts of our food from the metabolic cycle that produce anomalies (cancer), why is it so surprising that those mutations show up in RNA?  Why would we expect the golgi apparatus to synthesize something it wasn't intended / evolved to digest?

 

Please, I understand that miRNA is important, but other than the fact that someone in another language is researching what WE 811ers find to be blatantly obvious in physical observation... like, what's the digs?

 

I'm not cutting anyone up, I'm just lost as to the deeper significance.  Perhaps that's why I majored in English humanities and not biology.

 

Cheers,

PJ

Hi PJ, I think that the digs are that these types of findings may well help nudge people closer to eating they way we have already discovered to be so beneficial. 

 

So yeah, perhaps the study wont make a difference to someone who is already LFHCRV, but it may make a difference when that person is sharing with their friends/family, etc. So that's pretty cool :)

Aha, I get you now. :)

 

Yes, the winding paths of science can sometimes (or perhaps often) be inexplicably puzzling. Why do scientists still try to figure out what we know already. Sigh.

 

I still think that it is encouraging to see some progress in the right direction. The more scientific evidence for and explaining this lifestyle, the better.:)

The "organism that’s so different from mammals" they're referring to in the article is rice. I thought that was pretty clear, although I can see how it was ambiguous. 


In any case, although all this may be "well, duh" to 811ers, this study is important because it exposes the MECHANISM by which food affects gene expression. It's not just "oh, lots of fiber, lots of vitamins" it's the actual miRNA in the food that makes a difference too. I think this will lead to more research about the importance of raw fruits and vegetables for optimum health, which I'm excited to see!

Great info, thanks for sharing.

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