Turns out it's not exactly the caloric restriction that extends the life of people. It's the lowered amount of methionine as a result of the restriction since adequate levels of protein are not provided. Fruits and vegetables have considerably lower amounts of methionine essential amino acid. In large amounts, fruit and veg provide just enough methionine that's not high when consuming enough calories, equal to a calorie restriction SAD diet! The overall methionine content of plant-derived foods is lower than animal-derived foods
Lower methionine intake:
Lower levels of insulin --> lower IGF-1, glucose, and thyroid hormones
Delayed onset of clouding of the lens in the eye (cataracts)
Livers more resistant to oxidative stress
Decreased levels of mitochondrial oxidative damage
Encourages hormesis which leads to less corticosteroids (stress hormone)
Changes in glutathione (glutathione is protective against oxidative damage)
General decline in protein synthesis (may be protective against age-related decline)
In other words, calorie-restrictors cut their methionine intake simply by eating fewer calories...
Which means, when we eat enough calories of fruit and veg, we get low methionine and don't have to calorie restrict.
Of course, methionine is essential, as its biosynthesis provides for non-essential amino acids such as cysteine, carnitine, taurine, and lecithin.
I read about that too in New Scientist once. See a little summary I wrote here:
Soy protein concentrate, sesame flour are not accessible in nature.
Very little amounts of Brazil nuts are needed to exceed 10% fat, not providing enough methionine regardless. I never said that methionine is neccessarily harmful, as it is an essential amino acid, but provides benefit in lower amounts compared to SAD.
I provided one sample of a scientific study, you can always proofread and review whether physiological effects via biochemistry are presented correctly. These are two more if you wanted a non-gov source.
It's always intersting to read these things and connect it to our daily lives :)
Makes sense to me :)
Caloric restriction always seemed pretty nuts to me!
I kinda hope this is true as well, as it's not nice to believe that one of the best ways to eat in terms of life and longevity is also horribly boring and leads to you looking like a totally unhealthy stick insect xD
Didn't make much sense to me!
Cheers for this thread man :)
Think it like this:
They need around 2500 calories. But the restrict it to 1500 by moving less, getting into lower metabolism-mode (starvation mode) and living less.
By not putting in so much crap in their system, they don't need to put out so much either so they have an easier time flushing out the s***. They aren't getting behind the schedule and won't pile up crap as much.
By keeping both the fat and protein low automatically with CR they will get all the benefits that we get. That's why the high fat raw foodists get more benefits by practicing CR, by lowering their high fat + protein intake. But the lowered overall nutrient intake will also make them fail, hard time.